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Impact of Cigarette Smoke on RNA-cap Modifications within HIV Infected Cells

This R21 will undertake a series of vitro/ex vivo experiments to provide insights into the modifications to host and HIV-specific mRNAs in presence of both cART and cigarette smoke. Our focus is on the evaluation a newly identified 5' cap, Nicotinamide Adenine Dinucleotide (NAD+), for its ability to influence both HIV and host RNA expression in the background of HIV, antiretroviral drugs (ART) and cigarette smoke condensate (CSC). Our long-term goal is to determine if there is a role for the NAD+ 5'cap on HIV specific and/or cellular RNAs following both HIV infection and exposure to CSC. 

Active Dates 
05/01/2018 to 04/30/2020
Faculty Involved