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A rapid and specific diagnostic for immunoglobulin response to Zika virus exposure based on de novo designed low cost hyper-stable mini-protein epitopes

The recent Zika virus epidemic has caused concern worldwide, largely due to the link between the mosquito-born pathogen and a number of severe complications to fetuses carried by infected women. Current methods to test for presence of this virus are slow and often hindered by cross-reactivity to other viruses suggesting a pressing need for a way to rapidly and specifically test for Zika virus exposure. This project focuses on the computational design of novel viral epitope mimetics of the Zika envelope protein to be implemented in a low-cost instrument-free paper-based assay.

Active Dates 
10/01/2016 to 09/30/2019
Faculty Involved