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Generation/Isolation of Novel bNabs from Lymph Node B cells

The primary objective of the grant is the isolation of novel bNabs from the germinal centers of HIV-1 infected subjects. The aims of the subaward activities are to determine if the generation of rare bNabs is due to a block of B cell maturation or defective retention of B cell producing high-affinity antibody; and the determination of the presence of a maturation blockade in the B cell populations producing VRC01 class antibodies.

Active Dates 
11/05/2014 to 10/31/2017
Faculty Involved