- Affiliate Assistant Professor, Global Health
- Program Lead NTDs, IDRI
1616 Eastlake Ave E
Seattle, WA 98102
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Malcolm Duthie is Senior Director, Research at HDT Bio Corp. Malcolm's main research interest lies in determining and examining the host/pathogen interactions that initiate and control immune responses, how these interactions can be beneficially manipulated, and, ultimately, their practical application within disease control programs.
Malcolm received his training through a BSc (Hons) Immunology from the University of Glasgow, Scotland, and a Ph.D. in Medical Microbiology from the University of Edinburgh, Scotland. His main research interests lie in determining and examining the host/pathogen interactions that initiate and control immune responses, how these interactions can be beneficially manipulated, and ultimately, their practical application within disease control programs. An emphasis is placed on emerging infections and neglected tropical diseases. This research uses preclinical models of immunization and infection to determine mode-of-action of early stage vaccine candidates. It also capitalizes on an extensive collaborative network across several countries to identify vaccine candidates and develop new diagnostic tools to improve the control of COVID-19, influenza, leprosy, leishmaniasis and Chagas disease.
Malcolm is currently an Affiliate Assistant Professor, Department of Global Health, University of Washington School of Medicine, Seattle, and previously served as a Visiting Professor to the CAPES-Fiocruz/CDTS long-term collaboration program in Brazil and a Foreign Expert Consultant to Center for Major Infectious Disease, Capital Medical University, Beijing, China. Malcolm serves as a member of the Editorial Board of Infection and Immunity (2012-) and is a member of the American Association of Immunologists, American Society for Microbiology and American Society of Tropical Medicine and Hygiene, and British Society for Immunology.
- PhD (University of Edinburgh (UK))
- BSc (University of Glasgow (UK))
- Drug and Vaccine Development
- Host-Pathogen Interactions
- Infectious Diseases
- Neglected Diseases, Tropical Medicine (incl. Parasites)
Duthie MS, Pena MT, Ebenezer GJ, Gillis TP, Sharma R, Cunningham K, Polydefkis M, Maeda Y, Makino M, Truman RW et al: LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection. NPJ Vaccines 2018, 3:12.
Duthie MS, Pereira L, Favila M, Hofmeyer KA, Reed SJ, Metangmo S, Townsend S, Laurance JD, Picone A, Misquith A et al: A defined subunit vaccine that protects against vector-borne visceral leishmaniasis. NPJ Vaccines 2017, 2:23.
Duthie MS, Orcullo FM, Abbelana J, Maghanoy A, Balagon MF: Comparative evaluation of antibody detection tests to facilitate the diagnosis of multibacillary leprosy. Appl Microbiol Biotechnol 2016, 100(7):3267-3275.
Duthie MS, Orcullo FM, Maghanoy A, Balagon M: Need for, and acceptability of, rapid diagnostic tests that can facilitate the diagnosis of leprosy. Leprosy Review 2016, in press.
Duthie MS, Guderian JA, Vallur AC, Misquith A, Liang H, Mohamath R, Luquetti AO, Carter D, Tavares SN, Reed SG: Multi-epitope proteins for improved serological detection of Trypanosoma cruzi infection and Chagas Disease. Diagn Microbiol Infect Dis 2016, 84(3):191-196.