Dr. James Kublin is currently Executive Director of the HIV Vaccine Trials Network and the COVID-19 Prevention Network based at Fred Hutch. He is also the Medical Director of the Malaria Clinical Trials Center and a faculty member in the Department of Global Health at the University of Washington. Dr. Kublin has conducted extensive research on HIV, TB and malaria, including clinical trials of novel therapies and vaccines. Jim has a long history working with disadvantaged and refugee populations in South and Central America, Southeast Asia and Africa. He was a faculty member at the University of Malawi, College of Medicine, and provided training throughout Africa on epidemiology, malaria, and HIV. Jim continued work in vaccine development and molecular epidemiology while attending the University of Maryland’s School of Medicine for his fellowship in Vaccinology at the Center for Vaccine Development. BMGF awarded Jim a Grand Challenges Exploration award to apply high-throughput system analyses to malaria vaccine development. More recently, Jim is investigating the role of the microbiome in modulating immune responses in HIV and TB vaccine clinical trials and gnotobiotic mouse models.