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Projects 643
Countries 131
Faculty 435
Health Topics 141

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The HIV-1 capsid assembly pathway: cellular factors and links to pathogenesis

The Lingappa lab studies viral host interactions involved in assembly of human immunodeficiency virus type 1 (HIV-1) and other viruses.  Previously, our group demonstrated that immature HIV-1 capsid assembly in cells occurs through a pathway of assembly intermediates, and is facilitated by the catalytic activity of the host enzymes ABCE1 and DDX6.  Our recent studies show that ABCE1 binds directly to HIV Gag through an ancient binding site that is present even in the Ty3 retrotransposon Gag protein.  One current project in the lab involves understanding the evolution of the ABCE1 binding site in different retroviral Gag proteins.  A second project in the lab involves studying how HIV-1 genomic RNA is packaged into the assembling virus in cells.  A third project address how polymorphisms that arise in Gag in vivo can enhance ABCE1-Gag binding, thereby accelerating the kinetics of assembly and increasing virus particle production.  The latter studies have important implications for viral pathogenesis, since they test the hypothesis that altering viral-host interactions during assembly could impact viral set point and viral load.  The Lingappa lab’s studies have also led to development of novel antiretroviral compounds that inhibit virus replication by acting on the capsid assembly pathway.

Active Dates 
01/01/2002 to 12/31/2018
Faculty Involved 
Health Topics